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As a professional, full time trader and hedge fund manager, I am always looking for

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

interesting trivial in the US stock markets. Here is a list of 10 of the most inte

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

resting ones that I have collected so far.

1. Chances are better than 2 to 1 that

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

n the next time period, the stock will move in the same direction it did in the las

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t time period.

2. If a stock makes a large move (over 10%) in a single month perio

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

, the odds are greater than 2 to 1 that it will move in the opposite direction in t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

he next monthly period.

3. Trends tend to persist for a significant period of time

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

therefore betting against the trend is dangerous.

4. Friday is the best day for t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

he market, and Monday is the worst. Fridays have averaged an increase of 0.085% whi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e Mondays have averaged a decrease of 0.089% over the last 50 years.

5. For the pa

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

st 50 years, the gain in the Dow-Jones Industrial average during the first six cale

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ndar days of each month has been greater than the entire gain for the month.

6. Ov

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

r the past 50 years, chances are a better than 2 to 1 that the Dow will rise on Chr

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

istmas Week against the previous week. We call this the “Santa Claus Rally”.

7. Ov

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

r the past 4 years (2001 – 2005) , the stock markets have fell on the last trading

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

day before Christmas.

8. The lowest level the Dow has ever gone to is 40.60 points

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

on 3rd July 1933.

9. The Dow Jones Industrials Index has existed since 1915 while

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

the Nasdaq Composite Index has only existed since 1990.

10. Berkshire Hathaway A

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

tock continues to be the most expensive stock trading in the US market at the time

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

of this writing.

Hope these trivial have entertained and informed you in some ways

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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