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In recent months, many advisors have talked a lot about the wisdom of investing overseas, but most have failed to really address the way to do that. For new investors, in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

vesting in the U.S. is challenging enough, but investing across borders is often even more daunting.

Many major issues need to be addressed, but the first step is decidin

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

g how to buy and sell. Here are some possibilities:

1. Direct purchase in foreign markets. The most straightforward way to invest in foreign markets is by buying shares

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

directly in the regional or national markets. This approach has some drawbacks, however. First, one must buy through an account with a broker who is registered in that n

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ation. For Canadian shares, this is relatively easy, since many U.S. brokers connect with the Toronto exchange. But going beyond that zone leaves us with few, and expens

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ve, choices. Plus, shares on many foreign exchanges are not subject to the same reporting requirements as those on the NYSE or even the NASDAQ. Thus, we may not know eno

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ugh about the financial status of many international companies available in this way. Also, since these shares sell in foreign currency, we must calculate all the exchang

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rates.

2. ADR’s. American Depository Receipts are foreign stocks (actually, certificates representing those stocks) selling on American markets. As such, they are requ

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ired to fulfill all the reporting requirements and laws that U.S. stocks are, and hence are much more transparent. Plus, the shares are priced in U.S. dollars, simplifyin

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

the purchase process. ADR’s are the most common method for American investors to invest in foreign stocks, and include a number of the names I have recommended in the pa

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

st, including Unilever, Telefonos de Mexico, America Movil, Korea Electric, Canon, Nokia, and Bancolombia, among others.

3. American multinationals. An even simpler way

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

to play foreign markets is to invest in American companies that do business overseas. Companies like Apple, Coke, and Procter & Gamble do almost as much business around t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e world as they do here in the U.S.

4. International mutual funds. Mutual funds simplify the process of investing overseas. A buyer can purchase one fund which may hold

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

dozens of different stocks that the fund managers have researched.

5. International Index Funds: Exchange Traded Funds, such as iShares (formerly known as WEBs), are ben

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hmark indices of foreign markets. Buying an index allows one to gain from a wide market rather than trying to research individual stocks.

6. Closed-end Country Funds. L

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ike the index funds above, country funds focus on a particular market. The difference is that these funds are actively managed, and may often be available at a discount t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the value of their shares. If one watches carefully, one can occasionally take advantage of great deals in these shares, which trade just like stocks. Some examples are

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

the Swiss Helvetia Fund, the Brazil Fund, or the New Ireland Fund. Closed-end funds may also be available that invest across national borders, such as the Emerging Marke

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

s Telecom Fund, the Templeton Dragon Fund, or the Latin American Discovery Fund.

In the end, there are many ways to invest internationally. Use good judgment, but be sur

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e to take advantage of the opportunity to diversify across borders. One thing is for sure: there’s no longer any excuse for keeping all your eggs in one (national) basket

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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