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Amortization describes the process of dividing mortgage payments over the term of the l

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

oan between interest paid and principal repayment. Mortgages loans are front loaded wi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

th interest; this means at the beginning of the loan you are paying more in interest th

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

an you are repaying on the principal balance. This works in your favor at the end of t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e mortgage because the interest is calculated on the remaining balance. The smaller yo

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ur outstanding balance, the less you will pay in interest.

For example, if you were to

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

borrow $100,000 for your home at 6.5% interest over 30 years your monthly payment woul

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

be $630. When you make your first payment $540 of the $630 will be paid to interest.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

This means you will only pay $90 towards the principal balance of your loan. This fro

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

nt loading of interest makes it very difficult to build equity in your home during the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

arly years of your mortgage.

Every month that you make a payment the amount of interes

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

t you pay is based on the outstanding balance of the mortgage. In this case, the secon

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

d payment you make the interest will be based on a balance of $99,910. By using an amo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rtization table you will be able to see how the interest amount you pay decreases as th

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

principal balance is paid down.

By the time you reach the halfway point in repayment

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

of the mortgage, you will have made 256 monthly payments over the course of 21 years.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

The remaining balance will be paid back in 9 years. The fact that you will not pay bac

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

half of a 30 year mortgage for the first 21 years is a strong case for making bi-weekl

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

y mortgage payments. By making bi-weekly payments you can significantly reduce the amo

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

unt of interest paid over the life of the mortgage, and pay off the balance much faster

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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