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According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

rticle, we will discuss submitting your web site address to the numerous search en

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

gines.

There are well over 200 hundred search engines on the Internet. You may be

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

familiar with the most well known search engines, of Google, Yahoo and MSN. Thes

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e sites are considered the big three of the search engine world, but there are man

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

y more. Here is a short list of ten search engine sites that you may or may not b

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e familiar:

• www.Altavista.com
• www.Lycos.com
• www.Excite.com
•

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

www.AskJeeves.com
• www.Exactseek.com
• www.Hotbot.com
• www.Allthe

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

web.com
• www.iwon.com
• www.Looksmart.com
• www.Overture.com

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

When you have your site up and running, one of the first tasks you should assign y

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ourself is to begin submitting your site URL to all of the search engines that wil

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

l accept your site. URL stands for Uniform Resource Locator. Your URL is your we

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

b site address starting with “www” and ending with “com, net, or org”. To find th

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e submission page for the search engine, look for a link that says “Submit your UR

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

”. This link is typically located at the bottom of the home page for the most pro

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

minent search engines, while for the less prominent they are located at the top.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

You can even use search engine submission services to submit your site URL to the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

various search engines. For a list of submission sites, just type “Free URL Submi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ssion” into any one of the search engines mentioned above and you should get ample

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

options. Do not pay for any submission services, there are enough free offerings

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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