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To replace the current running configuration with a saved Cisco IOS configuration file, use the configure replace command in privileged EXEC mode.

R

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

outer#configure replace flash:test.cfg

This command will replace (NOTE: not merge) the running config with the config in file test.cfg. This comman

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d was introduced in 12.3(7)T

Here is an example of the effect:

Router#sh ip int brief

Interface IP-Address

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

OK? Method Status Protocol

FastEthernet0/0 10.10.10.3 YES manual up up

FastEthernet0/1 10.1.1.1 Y

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

S manual up up

Serial0/3/0 unassigned YES unset administratively down down

Router#configure replace fl

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ash:test.cfg

This will apply all necessary additions and deletions

to replace the current running configuration with the

contents of the specifie

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

d configuration file, which is

assumed to be a complete configuration, not a partial

configuration. Enter Y if you are sure you want to proceed. ? [no]:

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rong>y

Total number of passes: 1

Rollback Done

r1#

Dec 18 00:44:05.927: Rollback:Acquired Configuration lock.

Dec 18 00:44:07.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

703: %PARSER-3-CONFIGNOTLOCKED: Unlock requested by process '3'.

Configuration not locked.

Dec 18 00:44:08.819: %LINK-5-CHANGED: Interface FastEthernet0/1,

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

changed state to administratively down

r1#sh ip int brief

Interface IP-Address OK? Method Status Protocol

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

FastEthernet0/0 10.10.10.3 YES manual up up

FastEthernet0/1 10.1.1.1 YES manual administratively down down

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Serial0/3/0 unassigned YES unset administratively down down

NOTE the following:

1) Router name has changed

2)

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

FastEthernet 0/1 no longer has an IP address

3) FastEthernet 0/1 is shutdown

This is great as rather than just MERGING a config, the command REPLAC

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ES the config. You can replace the running-config from many places:

r1#configure replace ?

archive: URL of config file that will replace running-c

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

nfig

cns: URL of config file that will replace running-config

flash: URL of config file that will replace running-config

ftp: URL of config file that will

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

replace running-config

http: URL of config file that will replace running-config

https: URL of config file that will replace running-config

null: URL of

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

config file that will replace running-config

nvram: URL of config file that will replace running-config

pram: URL of config file that will replace running-

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

onfig

rcp: URL of config file that will replace running-config

scp: URL of config file that will replace running-config

system: URL of config file that wi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ll replace running-config

tftp: URL of config file that will replace running-config

xmodem: URL of config file that will replace running-config

ymodem: UR

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

L of config file that will replace running-config

You could thus have a backup config in flash or on a TFTP server and restore immediately to running config

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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