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Since early 1990's, Online game has become a spectacularly booming industry in the world. International Data Corporation’s 2004

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

statistic showed global Online game’s income was $ 8.2 billion and an estimated of $22.7 billion in 2009. In China, the bigges

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

online game market, those numbers were $300 million and $1.3 billion respectively.

What is the source of all this?

Th

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

newborn Online game has dislodged PC game and Console game from their firm positions as Online game is always available for up

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ating, creating new functions and expanding game world’s map. If life cycle of a PC game or Console game is: Introduction – Gro

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

th – Upgrade – Decline, it is quite different with Online game: Introduction – Growth – Outdating – Upgrade – Outdating – Upgra

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e…Thus, even pro game players who know all secrets of Final Fantasy, Fallout, etc. cannot boast “I am an expertise of The S

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ms or Warcraft”.

Furthermore, Online game is actually a huge community of old and new members as once upgraded, every play

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

r has to grope for a brand new adventure with unlimited exciting and thrilling stage. The phrase “MMORPG” (Massively Mul

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

iplayer Online Role Playing Game) becomes more popular than ever and no longer do players have to face monotonous individual ga

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es but they can now interact with hundreds or thousands of other players from all over the world.

It can be said without exagg

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

eration that the players can live a real life in virtual world of Online game. They gather in one side and undertake the advent

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

re of a lifetime together, such as fighting and protecting Human or Ak’kan clan in Risk Your Life II, or borrow money, or trade

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

weapons. All real emotions are shown when playing Online games: glad when winning, satisfied when trading a valued weapon, or d

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

sappointed when being defeated. A current research of Avnex Ltd.

(www.audio4fun.com) found that many game geeks also use Voice

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

changer software (VCS) together with some chat application such as Ventrilo, Teamspeak to make the virtual games become vivid.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

CS can change their voice to multi-characters they are playing role in, regardless age and sex. Imagine that how much more inte

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

esting a sonorous voice of a knight, a charming voice of a heroic will make the game is. One game player shared in the research

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

interview: “That was a female character, and I did hear her sweet and sexy voice asking for my weapon. Of course I was falli

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

g into her flirtation. After a couple of days, it turned out that my weapon was in a class mate’s property. He used AV VCS”.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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