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One of the trends in Tourism is residential tourism. Each year thousand of families move from their home country to a new place on earth. This cou

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ld be for the sake of a better climate -- whether tax, investment, leisure, or just the weather -- or because of any other reason.

In Spain in

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

2002 non-residents purchased 90.000 homes with a value of 5.676 million Euros a 16% increase on 2001 (4.765 million Euros). In Malaga Province in

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

2002 non-residents purchased 36.000 homes valued at 2.270 million euros. Of those purchasing homes, 42% were British, 28% German, 7% French, 5% It

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lians, 3% Belgians. The investment in second homes by Spaniards is estimated at 2.000 million euros. (www.andalucia.com/spain/statistics/residenti

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

al_tourism.htm)

Germany was recently portrayed in the newspapers regarding this emigration. The Financial Times reported a historic maximum

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

f emigrants, leaving a deviation in the immigration-emigration balance: Destatis, the federal statistical office, estimates that 144,815 Ger

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

mans left the country last year. Though this marked a slight decrease from 2004, it was the first time that more had left the country than returne

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

since 1968… The previous emigration record of 1956 was breached in 1994 and, after several years of decline, the outflow began rising again in 20

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

01, and continued to rise up to 2004, although 2005's figure of 144,815 was slightly down on the year before.” (www.ft.com/cms/s/98dffe0c-3a1f-11d

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

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The impact for the traditional tourists sector is high. In the first place because the average spending is per tou

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

rist is lower; a residential tourist spends less on tourist related activities than a normal tourist. This is quite logical, because a residential

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

tourist gets used to the climate and will acquire new daily habits conform its origin. The state of mind of a residential tourist is different tha

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

n a normal tourist. Living near the beach will not automatically mean that you are having a holiday. A holiday is an exceptional period. Once you

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

re resident your situation is no longer exceptional, and you will adapt your spending pattern with it.

The magnetic effect around the individual

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

residential tourist is another important element in this change in the tourist sector. The Residential tourist invites family and relatives to joi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

them during the holidays or they are asked for taking care of their houses when they travel back. This magnetic effect is cultural; people that m

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ove do not want to loose the life they had at home. So you will find the satellite dish (with British, German and Dutch television), together with

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the foreign grocery shops and other economic activities that are highly concentrated as isolated cultures. Integration becomes an issue.

The net

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

effect on the Spanish economy is probably still positive, but for the traditional tourist sector this change is a real challenge.

© 2006 Hans Boo

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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